Next-Generation Proteomics at UC Davis
The Genome Center Proteomics Core is powered by the industry's most advanced fleet of mass spectrometers. From ultra-fast 4D-Proteomics™ to deep TMT quantification, our instruments are tailored to answer complex biological questions with speed and precision.
Bruker timsTOF HT
The Speed Demon: High-Throughput 4D-Proteomics™
The timsTOF HT redefines throughput without sacrificing depth. Utilizing Trapped Ion Mobility Spectrometry (TIMS) and PASEF® technology, this instrument unlocks the fourth dimension of proteomics: ion mobility.
- Unmatched Speed: Sequencing speeds up to 300 Hz enable deep proteome coverage in short gradients.
- CCS-Aware Identification: Uses Collisional Cross Section values for higher confidence ID.
- Clinical Proteomics: Ideal for large-cohort plasma studies and unbiased biomarker discovery.
Thermo Orbitrap Fusion Lumos
The Deep Diver: Tribrid Versatility
Combining a Quadrupole, Linear Ion Trap, and Orbitrap, the Lumos offers a "Tribrid" architecture designed for your most difficult samples. It excels at complex structural analysis and accurate quantification.
- Multiplexing Master: Features SPS-MS3 technology for accurate TMT quantification, eliminating ratio distortion.
- PTM Analysis: Superior performance for Phosphorylation, Glycosylation, and crosslinking studies.
- Versatile Fragmentation: Access to CID, HCD, and ETD modes for comprehensive peptide characterization.
Thermo Orbitrap Exploris 480
The Workhorse: Robustness Meets Precision
Streamlined for extraordinary day-to-day consistency, the Exploris 480 is the facility's choice for robust Data-Independent Acquisition (DIA) and large-scale quantitative studies.
- DIA Powerhouse: Optimized for quantifying thousands of proteins with high reproducibility across many samples.
- FAIMS Pro Interface: equipped with high-field asymmetric waveform ion mobility spectrometry to filter out interferences.
- Sensitivity: High-capacity transfer tube ensures maximum ion transmission for limited sample amounts.
At a Glance: Which Instrument Do You Need?
| Feature | Bruker timsTOF HT | Thermo Lumos | Thermo Exploris 480 |
|---|---|---|---|
| Best Application | High-Throughput, Clinical Cohorts, Short Gradients | Deep Dives, TMT Quant, PTMs, Crosslinking | DIA Quant, Routine Analysis, Label-Free Quant |
| Unique Tech | TIMS (Ion Mobility) & PASEF | Tribrid & SPS-MS3 | FAIMS Pro Interface |
| Throughput | Ultra-High (up to 300Hz) | Versatile / Standard | High / Robust |